Grace Gill graduated with a B.A. (Honors) in Molecular Biology from the University of California, Berkeley and went on to obtain her Ph.D. in Biochemistry at Harvard University. It was during her graduate work in the laboratory of Mark Ptashne that she began her studies on the molecular mechanisms that regulate transcription.
After post-doctoral work with Robert Tjian at the University of California, Berkeley, she was appointed to the faculty in the Department of Pathology at Harvard Medical School. In 2007, she moved to Tufts University School of Medicine where she is currently Associate Professor in the Developmental, Molecular and Chemical Biology Department. Dr. Gill’s research continues to address fundamental aspects of transcriptional regulation with a focus on how post-translational modifications contribute to gene expression in the nervous system and during tumorigenesis.
Research in the Gill laboratory is directed towards understanding the molecular mechanisms that regulate transcription. Failure to properly regulate transcription, that is to turn the right genes on or off at the right time and place, contributes to developmental defects and disease. Recent efforts have been investigating how post-translational modification of the transcription factors Sp3 and Sp4 by the small ubiquitin related modifier, SUMO, and other modifications contributes to complex programs of gene expression.