Sean Megason received a BS in Molecular Biology at the University of Texas at Austin in 1997. He performed his PhD in the laboratory of Andrew McMahon at Harvard on the control of organ size in the neural tube. He then went to Caltech for postdoctoral research in the laboratory of Scott Fraser on microscopy where he developed “in toto imaging”.
Dr. Megason started his laboratory at Harvard University in the Department of Systems Biology in 2008.
The Megason Lab uses imaging-based systems biology to elucidate the systems level principles of animal development. They are particularly interested in long standing problems in embryology whose understanding has defied molecular reduction namely patterning, morphogenesis, and size control.
The Megason Lab pursues these questions in the inner ear and spinal cord of zebrafish using a variety of techniques including microscopy, mathematical modeling, and molecular and mechanical perturbation.